PP98 Occupational Therapy For Adult Persons With Cognitive Impairments: A Systematic Overview On Clinical Efficacy

Introduction Damage to the central nervous system (CNS) in adulthood, may lead cognitive impairments. In Germany, occupational therapy is most often prescribed for neurological diagnoses, including stroke and traumatic brain injury (351 343 cases per 100,000, respectively 2018). For impairments, primarily remedies are sensorimotor-perceptive, motor-functional neuropsychologically oriented treatment or training of performance. Here we report results a health technology assessment (HTA) on clinical efficacy patients with Methods To assess efficacy, systematic overview was conducted based published reviews HTA reports from last ten years summarizing randomized controlled trials (RCTs) retrieved four bibliographic databases. The target population included adult impairments caused by diseases CNS, excluding moderate severe dementia. intervention studied compared no therapy. Outcomes were abilities, independence, self-determination, health-related quality life (QoL), participation activities daily living (ADL). Results Five comprising 1,316 included. There evidence small statistically significant positive effect “general function” (10 RCTs, n=470) ADL (4 n= 405). A non-quantified reported behavior control (1 RCT, n=96), conflicting QoL (2 n=214). No found individual components cognition (5 n=202), self-efficacy n=98) social n=194). level low all endpoints due high risk bias sample sizes. Conclusions Based this overview, it cannot be demonstrated but also not ruled out that impairment an effective adults very uncertain effects bias, statistical power, heterogeneity interventions study populations.